Epidemiological investigation of the association between infectious mononucleosis and multiple sclerosis
- PMID: 2062419
- DOI: 10.1159/000110248
Epidemiological investigation of the association between infectious mononucleosis and multiple sclerosis
Abstract
By matching a cohort of 494 infectious mononucleosis (IM) cases with a multiple sclerosis (MS) register, 3 MS cases were retrieved. The interval between IM and MS was 12 years. This corresponds to a relative risk of 3.7 for MS to occur subsequent to IM (p = 0.05). This relationship between a manifestation of a relatively late Epstein-Barr virus infection and MS may indicate that a microbiologically shielded environment is important in the pathogenesis of MS.
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