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. 2010 Aug;47(2):212-8.
doi: 10.1016/j.bone.2010.05.030.

Bioactive glass S53P4 as bone graft substitute in treatment of osteomyelitis

N C Lindfors  1 , P Hyvönen, M Nyyssönen, M Kirjavainen, J Kankare, E Gullichsen, J Salo
Affiliations

Bioactive glass S53P4 as bone graft substitute in treatment of osteomyelitis

N C Lindfors et al. Bone. 2010 Aug.

Abstract

Bioactive glass (BAG)-S53P4 is an osteoconductive bone substitute with proven antibacterial and bone bonding properties. In a multicentre study 11 patients with verified chronic osteomyelitis in the lower extremity and the spine were treated with BAG-S53P4 as a bone substitute. The cavitary bone defect and the surrounding of a spinal implant were filled with BAG-S53P4. The most common pathogen causing the infection was Staphylococcus aureus. The mean follow-up was 24 months (range 10-38). BAG-S53P4 was well tolerated. Nine patients healed without complications. One patient who achieved good bone formation sustained a superficial wound infection due to vascular problems in the muscle flap, and one patient had an infection due to a deep haematoma. This study shows that BAG-S53P4 is a good and well-tolerated bone substitute, and can be used in treatment of osteomyelitis with good primary results.

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