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Randomized Controlled Trial
. 2010 Jul 12;170(13):1161-7.
doi: 10.1001/archinternmed.2010.162.

An intensive behavioral weight loss intervention and hot flushes in women

Alison J Huang  1 , Leslee L Subak, Rena Wing, Delia Smith West, Alexandra L Hernandez, Judy Macer, Deborah Grady; Program to Reduce Incontinence by Diet and Exercise Investigators
Collaborators, Affiliations
Randomized Controlled Trial

An intensive behavioral weight loss intervention and hot flushes in women

Alison J Huang et al. Arch Intern Med. .

Erratum in

  • Arch Intern Med. 2010 Sep 27;170(17):1601

Abstract

Background: Higher body mass index is associated with worse hot flushes during menopause but the effect of weight loss on flushing is unclear.

Methods: Self-administered questionnaires were used to assess bothersome hot flushes in a 6-month randomized controlled trial of an intensive behavioral weight loss program (intervention) vs a structured health education program (control) in 338 women who were overweight or obese and had urinary incontinence. Weight, body mass index, abdominal circumference, physical activity, calorie intake, blood pressure, and physical and mental functioning were assessed at baseline and at 6 months. Repeated-measures proportional odds models examined intervention effects on bothersome hot flushes and potential mediating factors.

Results: Approximately half of participants (n = 154) were at least slightly bothered by hot flushes at baseline. Among these women, the intervention was associated with greater improvement in bothersome flushes vs control (odds ratio [OR] for improvement by 1 Likert category, 2.25; 95% confidence interval [CI], 1.20-4.21). Reductions in weight (OR, 1.32; 95% CI, 1.08-1.61; per 5-kg decrease), body mass index (1.17; 1.05-1.30; per 1-point decrease), and abdominal circumference (1.32; 1.07-1.64; per 5-cm decrease) were each associated with improvement in flushing, but changes in physical activity, calorie intake, blood pressure, and physical and mental functioning were not related. The effect of the intervention on flushing was modestly diminished after adjustment for multiple potential mediators (OR, 1.92; 95% CI, 0.95-3.89).

Conclusion: Among women who were overweight or obese and had bothersome hot flushes, an intensive behavioral weight loss intervention resulted in improvement in flushing relative to control. Trial Registration clinicaltrials.gov Identifier: NCT00091988.

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Figures

Figure 1
Figure 1
Recruitment, randomization, retention, and hot-flush reporting in the Program to Reduce Incontinence by Diet and Exercise trial.
Figure 2
Figure 2
Change in bothersome hot flushes during 6 months among women reporting bothersome symptoms at baseline by treatment assignment. P=.01 for difference in improvement in bothersome flushing by 1 Likert category between the intervention and control groups using repeated-measures proportional odds regression.
See this image and copyright information in PMC

References

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