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. 2010 Jul;67(7):819-25.
doi: 10.1001/archneurol.2010.144.

Dietary antioxidants and long-term risk of dementia

Elizabeth E Devore  1 , Francine Grodstein, Frank J A van Rooij, Albert Hofman, Meir J Stampfer, Jacqueline C M Witteman, Monique M B Breteler
Affiliations

Dietary antioxidants and long-term risk of dementia

Elizabeth E Devore et al. Arch Neurol. 2010 Jul.

Abstract

Background: The Rotterdam Study previously found that higher dietary intakes of vitamins E and C related to lower risk of dementia and Alzheimer disease (AD) over 6 years of follow-up.

Objective: To study consumption of major dietary antioxidants relative to long-term risk of dementia.

Design: Population-based prospective cohort study.

Setting: The Rotterdam Study in the Netherlands.

Participants: A total of 5395 participants, 55 years and older, who were free of dementia and provided dietary information at study baseline.

Main outcome measures: Incidence of dementia and AD, based on internationally accepted criteria, relative to dietary intake of vitamin E, vitamin C, beta carotene, and flavonoids.

Results: During a mean follow-up period of 9.6 years, dementia developed in 465 participants, of whom 365 were diagnosed as having AD. In multivariate models adjusted for age, education, apolipoprotein E epsilon4 genotype, total energy intake, alcohol intake, smoking habits, body mass index, and supplement use, higher intake of vitamin E at study baseline was associated with lower long-term risk of dementia (P = .02 for trend). Compared with participants in the lowest tertile of vitamin E intake, those in the highest tertile were 25% less likely to develop dementia (hazard ratio, 0.75; 95% confidence interval, 0.59-0.95 with adjustment for potential confounders). Dietary intake levels of vitamin C, beta carotene, and flavonoids were not associated with dementia risk after multivariate adjustment (P > .99 for trend for vitamin C and beta carotene and P = .60 for trend for flavonoids). Results were similar when risk for AD was specifically assessed.

Conclusion: Higher intake of foods rich in vitamin E may modestly reduce long-term risk of dementia and AD.

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Conflict of interest statement

Conflict of interest: Authors report no conflicts of interest.

References

    1. Behl C. Amyloid beta-protein toxicity and oxidative stress in Alzheimer’s disease. Cell Tissue Res. 1997 Dec;290(3):471–480. - PubMed
    1. Christen Y. Oxidative stress and Alzheimer disease. Am J Clin Nutr. 2000 Feb;71(2):621S–629S. - PubMed
    1. Montiel T, Quiroz-Baez R, Massieu L, Arias C. Role of oxidative stress on beta-amyloid neurotoxicity elicited during impairment of energy metabolism in the hippocampus: protection by antioxidants. Exp Neurol. 2006 Aug;200(2):496–508. - PubMed
    1. Rota C, Rimbach G, Minihane AM, Stoecklin E, Barella L. Dietary vitamin E modulates differential gene expression in the rat hippocampus: potential implications for its neuroprotective properties. Nutr Neurosci. 2005 Feb;8(1):21–29. - PubMed
    1. Yamada K, Tanaka T, Han D, Senzaki K, Kameyama T, Nabeshima T. Protective effects of idebenone and alpha-tocopherol on beta-amyloid-(1-42)-induced learning and memory deficits in rats: implication of oxidative stress in beta-amyloid-induced neurotoxicity in vivo. Eur J Neurosci. 1999 Jan;11(1):83–90. - PubMed

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