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. 1991 Jun 25;19(12):3269-74.
doi: 10.1093/nar/19.12.3269.

Two hypervariable minisatellite DNA binding proteins

W P Wahls  1 , G Swenson, P D Moore
Affiliations
Free PMC article

Two hypervariable minisatellite DNA binding proteins

W P Wahls et al. Nucleic Acids Res. .
Free PMC article

Abstract

Hypervariable minisatellite DNA sequences are short, tandemly repeated sequences present at numerous loci in eukaryotes. They stimulate intermolecular homologous recombination up to 13-fold in human cells in culture and may be specific sites for the initiation of recombination in the eukaryotic genome (Wahls, W.P., Wallace, L.J., & Moore, P.D. (1990) Cell 60, 95-103). Reported here is the detection and partial purification of two hypervariable minisatellite DNA binding proteins, called Msbp-2 and Msbp-3, present in the nuclear extracts of human HeLa cells. The proteins elute from a gel filtration column with a native mass of 200-250 kDa and have sizes of 77 kDa and 115 kDa respectively.

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References

    1. Nature. 1988 Nov 24;336(6197):348-52 - PubMed
    1. Nature. 1988 Oct 20;335(6192):683-9 - PubMed
    1. Cytogenet Cell Genet. 1988;48(3):152-5 - PubMed
    1. Cell. 1990 Jan 12;60(1):95-103 - PubMed
    1. Nucleic Acids Res. 1990 Feb 11;18(3):625-9 - PubMed

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