[The effect of flurbiprofen axetil on laparoscopic cholecystectomy]

Abstract

Objective: To evaluate whether administration of flurbiprofen axetil before elective laparoscopic cholecystectomy can affect the BIS index and hemodynamics.

Method: Sixty patients scheduled for elective laparoscopic cholecystectomy were randomized into two groups. Flurbiprofen axetil 1 mg/kg was used intravenous 15 minutes before induction of general anesthesia in group B, while group A without premedication. Total intravenous anesthesia was maintained with propofol TCI. BIS index, blood pressure and heart rate were recorded at the time just before induction, after endotracheal intubation, 5 minutes before incision, incision, 5, 10, 15, 20 and 25 mins after incision.

Result: There were no significant difference between two groups in BIS index during period of anesthesia and awareness (all P > 0.05). Compared with group A, both systolic and diastolic blood pressure in group B at time of incision (T(1)) are apparently lower (P < 0.05). While, blood pressures were no significant different at other time (all P > 0.05).

Conclusion: In this study, administration of flurbiprofen before surgery of laparoscopic cholecystectomy did not alter BIS and the degree of sedation during total intravenous anesthesia. But it can reduce the harmful stimulation to cardiovascular reaction from surgery and make hemodynamic status more stable. Flurbiprofen can be safely and effectively used on elective laparoscopic cholecystectomy.