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. 2010 Sep;34(9):1169-74.
doi: 10.1016/j.leukres.2010.04.012. Epub 2010 Jun 3.

Aberrant microRNA expression pattern in myelodysplastic bone marrow cells

Kais Hussein  1 , Katharina Theophile, Guntram Büsche, Brigitte Schlegelberger, Gudrun Göhring, Hans Kreipe, Oliver Bock
Affiliations

Aberrant microRNA expression pattern in myelodysplastic bone marrow cells

Kais Hussein et al. Leuk Res. 2010 Sep.

Abstract

The microRNA/miR system might contribute to deregulation of cell homeostasis/disease phenotype. This is the first approach to generate an expression profile of 365 microRNAs in myelodysplastic syndromes (MDS) with normal karyotype (n=12) and distinct cytogenetic aberrations (n=12). In MDS-del(5q), a series of microRNAs not in the 5q-region was increased. MicroRNAs encoded on chromosomes 5, 7 and 8 were not differentially expressed in MDS with del(5q), -7 or +8. Evaluation in a larger cohort could confirm the up-regulation of the miR-1 in MDS. These findings provide evidence that MDS-haematopoiesis is distinct in its microRNA-expression pattern from non-neoplastic cells.

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