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. 2010 Dec;68(12):2117-24.
doi: 10.1016/j.apradiso.2010.05.008. Epub 2010 May 16.

Potential value of color-coded dynamic breast-specific gamma-imaging; comparing (99m)Tc-(V)-DMSA, (99m)Tc-MIBI, and (99m)Tc-HDP in a mouse mammary tumor model

Fijs W B van Leeuwen  1 , Tessa Buckle, Lukas Batteau, Bert Pool, Michiel Sinaasappel, Jos Jonkers, Kenneth G A Gilhuijs
Affiliations

Potential value of color-coded dynamic breast-specific gamma-imaging; comparing (99m)Tc-(V)-DMSA, (99m)Tc-MIBI, and (99m)Tc-HDP in a mouse mammary tumor model

Fijs W B van Leeuwen et al. Appl Radiat Isot. 2010 Dec.

Abstract

Using a mouse mammary tumor model based on orthotopic transplantation of luciferase-expressing mouse ILC cells (KEP1-Luc cells), we evaluated the diagnostic value of three clinically applied tracers: (99m)Tc-(V)-DMSA, (99m)Tc-MIBI, and (99m)Tc-HDP. Uptake of the tracers is compared using static and dynamic imaging procedures. We found that dynamic imaging in combination with pixel-by-pixel color coding has an added value over (high resolution) static imaging procedures. Such dynamic imaging procedures could enhance the potential of breast-specific gamma-imaging.

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