Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Jul 15;16(14):3754-9.
doi: 10.1158/1078-0432.CCR-10-0439. Epub 2010 Jul 13.

Ten common genetic variants associated with colorectal cancer risk are not associated with survival after diagnosis

Albert Tenesa  1 , Evropi Theodoratou, Farhat V N Din, Susan M Farrington, Roseanne Cetnarskyj, Rebecca A Barnetson, Mary E Porteous, Harry Campbell, Malcolm G Dunlop
Affiliations

Ten common genetic variants associated with colorectal cancer risk are not associated with survival after diagnosis

Albert Tenesa et al. Clin Cancer Res. .

Abstract

Purpose: To date, genomewide association studies have identified 10 genetic loci associated with colorectal cancer (CRC) susceptibility. We hypothesized that these loci might also affect cancer survival.

Experimental design: To determine whether single-nucleotide polymorphisms tagging these 10 loci influenced all-cause and CRC-specific mortality, we prospectively followed survival outcomes for 2,838 Scottish patients recruited soon after a diagnosis of CRC. Survival analysis was conducted using Cox proportional hazard models adjusted for American Joint Committee on Cancer stage, age, and sex.

Results: None of the single-nucleotide polymorphisms were found to be statistically significantly associated with all-cause or CRC-specific mortality.

Conclusions: We conclude that none of the 10 common genetic variants thus far shown to be associated with CRC risk are associated with survival from CRC.

PubMed Disclaimer

References

    1. Koessler T, Azzato EM, Perkins B, et al. Common germline variation in mismatch repair genes and survival after a diagnosis of colorectal cancer. Int J Cancer. 2009;124:1887–91. - PubMed
    1. Leitch EF, Chakrabarti M, Crozier JE, et al. Comparison of the prognostic value of selected markers of the systemic inflammatory response in patients with colorectal cancer. Br J Cancer. 2007;97:1266–70. - PMC - PubMed
    1. Galon J, Fridman WH, Pages F. The adaptive immunologic microenvironment in colorectal cancer: a novel perspective. Cancer Res. 2007;67:1883–6. - PubMed
    1. Lindstrom LS, Hall P, Hartman M, Wiklund F, Gronberg H, Czene K. Familial concordance in cancer survival: a Swedish population-based study. Lancet Oncol. 2007;8:1001–6. - PubMed
    1. Kim JG, Chae YS, Sohn SK, et al. Vascular endothelial growth factor gene polymorphisms associated with prognosis for patients with colorectal cancer. Clin Cancer Res. 2008;14:62–6. - PubMed

Publication types