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. 1991 Jul 1;88(13):5829-31.
doi: 10.1073/pnas.88.13.5829.

Lactate rise detected by 1H NMR in human visual cortex during physiologic stimulation

J Prichard  1 , D Rothman, E Novotny, O Petroff, T Kuwabara, M Avison, A Howseman, C Hanstock, R Shulman
Affiliations

Lactate rise detected by 1H NMR in human visual cortex during physiologic stimulation

J Prichard et al. Proc Natl Acad Sci U S A. .

Abstract

Brain lactate concentration is usually assumed to be stable except when pathologic conditions cause a mismatch between glycolysis and respiration. Using newly developed 1H NMR spectroscopic techniques that allow measurement of lactate in vivo, we detected lactate elevations of 0.3-0.9 mM in human visual cortex during physiologic photic stimulation. The maximum rise appeared in the first few minutes; thereafter lactate concentration declined while stimulation continued. The results are consistent with a transient excess of glycolysis over respiration in the visual cortex, occurring as a normal response to stimulation in the physiologic range.

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