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Review
. 2010 Oct;22(5):261-9.
doi: 10.1016/j.smim.2010.04.015. Epub 2010 Jul 13.

Notch regulation of early thymocyte development

Yumi Yashiro-Ohtani  1 , Takuya Ohtani, Warren S Pear
Affiliations
Review

Notch regulation of early thymocyte development

Yumi Yashiro-Ohtani et al. Semin Immunol. 2010 Oct.

Abstract

Notch signaling plays multiple roles in T cell development. Following thymic entry, Notch signals are required to specify the T cell fate from a multipotent hematopoietic progenitor. At subsequent steps in early T cell development, Notch provides important differentiation, survival, proliferation and metabolic signals. This review focuses on the multiple functions of Notch in early T cell development, from T cell specification in the thymus through beta selection.

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