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. 2010 Dec;29(12):1118-22.
doi: 10.1097/INF.0b013e3181ed9f4c.

Associations of proinflammatory cytokine levels with lipid profiles, growth, and body composition in HIV-infected children initiating or changing antiretroviral therapy

Joseph S Cervia  1 , Caroline J Chantry, Michael D Hughes, Carmelita Alvero, William A Meyer 3rd, Janice Hodge, Peggy Borum, Jack Moye Jr, Stephen A Spector; PACTG 1010 Team
Collaborators, Affiliations

Associations of proinflammatory cytokine levels with lipid profiles, growth, and body composition in HIV-infected children initiating or changing antiretroviral therapy

Joseph S Cervia et al. Pediatr Infect Dis J. 2010 Dec.

Abstract

Objectives: To measure proinflammatory cytokines (PIC) in HIV-infected children beginning or changing antiretroviral therapy (ART), evaluating associations with virologic, immunologic, serum lipid, growth, and body composition measures, markers of growth hormone action and glucose metabolism.

Methods: Forty-nine prepubertal HIV-infected children had measurements of viral load (VL), CD4 lymphocyte count and percentage, serum lipids, apolipoprotein AI/B, IGF-1, IGFBP-1, and IGFBP-3, anthropometry, bioelectrical impedance analysis, TNF-α, IL-1 β, and IL-6 at baseline and 48 weeks of ART.

Results: Baseline levels were detectable (>0.1 pg/mL) for IL-1 β in 28 of 48, and for TNF-α and Il-6 in all 49 children. TNF-α decreased with ART (P < 0.001) and IL-6 demonstrated a similar trend (P = 0.065). Children with 48-week VL <400 copies/mL had greater declines in TNF-α (mean 45%) than subjects with higher VL (5%; P = 0.009). Each 10% improvement in CD4% was associated with 26% lower TNF-α (P = 0.002) and 31% lower IL-6 (P = 0.016). Greater reductions in TNF-α were associated with lower total/HDL cholesterol ratio (P = 0.003) at week 48.

Conclusions: In HIV-infected children initiating or changing ART, PIC were detectable at baseline and decreased over 48 weeks. Better immunologic responses were associated with greater reductions in TNF-α and IL-6. Reductions in TNF-α were associated with improved total/HDL cholesterol ratio.

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Conflict of interest statement

The authors have no relevant conflicts.

Figures

Figure 1
Figure 1
Association of fat-free mass (FFM) z-scores with IL6-beta levels at baseline (N=24 children aged 8 years or older as NHANES only measured FFM in this age range). Line is the estimated linear regression (p=0.014).
Figure 2
Figure 2
Associations of apolipoprotein AI and IGFBP-1 levels with IL6-beta levels at baseline (N=35 and 27 children, respectively, with data available). Lines are the estimated linear regression (p=0.062 and p=0.005 in unadjusted analysis; p=0.017 and p=0.003 with adjustment for age, sex and race/ethnicity).
Figure 3
Figure 3
Association of change in log10 TNF-α and change in CD4 percentage between baseline and week 48 (N=35 with data available).
Figure 4
Figure 4
Association of change in log10 total/HDL cholesterol ratio and change in log 10 TNF-α between baseline and week 48 (N=30 with data available).
See this image and copyright information in PMC

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