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Editorial
. 2010 Aug;78(3):231-4.
doi: 10.1038/ki.2010.158.

JAK/STAT signaling in renal diseases

Peter Y Chuang  1 , John C He
Affiliations
Free article
Editorial

JAK/STAT signaling in renal diseases

Peter Y Chuang et al. Kidney Int. 2010 Aug.
Free article

Abstract

The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is a pleiotropic cascade essential to cytokine and growth hormone receptor signaling. Signaling through the JAK/STAT pathway is important for the kidney's response to injury in disease. Pang et al. confirm that activation of STAT3 mediates renal fibrosis in the unilateral ureteral obstruction experimental model.

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