Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1978 Feb 28;25(1):19-21.
doi: 10.1007/BF02010746.

The influx of pyrophosphate ions into calvaria in vitro

M W Neuman, W F Neuman, H Fleisch

The influx of pyrophosphate ions into calvaria in vitro

M W Neuman et al. Calcif Tissue Res. .

Abstract

The flux of 32P-labeled inorganic pyrophosphate (PPi) into bone was studied in vitro using Ussing chamber techniques and calvaria from newborn rat pups. Because insignificant hydrolysis and backflux of PPi took place under experimental conditions, it was possible to study the penetration of bone membranes by PP1 unambiguously. At physiological concentrations, the influx was found to be linearly concentration dependent and to follow first order kinetics, apparently a simple diffusion process. In magnitude, the intrinsic constant for influx was found to be approximately one-half that of inorganic phosphate ions under comparable conditions.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Biochim Biophys Acta. 1973 Oct 11;323(2):267-75 - PubMed
    1. Am J Physiol. 1966 Sep;211(3):821-5 - PubMed
    1. Nature. 1966 Nov 26;212(5065):901-3 - PubMed
    1. Proc Soc Exp Biol Med. 1966 Jun;122(2):317-20 - PubMed
    1. Calcif Tissue Res. 1976 Apr 20;(2):151-8 - PubMed

Publication types