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Case Reports
. 2010 Aug;33(8):E7-12.
doi: 10.1002/clc.20463.

Transcoronary bone marrow-derived progenitor cells in a child with myocardial infarction: first pediatric experience

Alisa Limsuwan  1 , Pavit Pienvichit, Thosaphol Limpijankit, Pongsak Khowsathit, Suradej Hongeng, Ratanaporn Pornkul, Suvipaporn Siripornpitak, Sarana Boonbaichaiyapruk
Affiliations
Case Reports

Transcoronary bone marrow-derived progenitor cells in a child with myocardial infarction: first pediatric experience

Alisa Limsuwan et al. Clin Cardiol. 2010 Aug.

Abstract

Background: Recent advances in stem cell therapy to restore cardiac function have great promise for patients with congestive heart failure after myocardial infarction in an adult population.

Objective: We examined the benefits of bone marrow-derived progenitor cells treatment modality for the pediatric patient.

Methods and results: We present our first case of transcoronary autologous stem cell transplantation in a 9-year-old girl with refractory congestive heart failure secondary to myocardial infarction 1 year after transcatheter revascularization. The child received daily injections of granulocyte colony-stimulating factor for 3 days prior to the bone marrow aspiration. The bone marrow cells were isolated to constitute CD133+/CD34+ more than 90% of the total number. Subsequently, the progenitor cell suspension was injected via a transcoronary catheter without any complication. Three months after stem cell therapy, her cardiac function, assessed by both cardiac magnetic resonance and echocardiogram, has been improved with the left ventricular ejection fraction at 47% compared to the baseline of 30%.

Conclusion: This is the first reported pediatric case of successful transcoronary injection of bone marrow-derived progenitor cells for end-stage heart disease. The procedure is considered safe and feasible for the pediatric population.

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Figures

Figure 1a
Figure 1a
The MRI evaluates the left ventricular function during systole and diastole from the four chamber view before stem cell injection
Figure 1b
Figure 1b
The MRI evaluates the left ventricular function during systole and diastole from the four chamber view after stem cell injection
Figure 2a
Figure 2a
The MRI evaluates the left ventricular function during systole (upper panel) and diastole (lower panel) from the short axis view before stem cell therapy
Figure 2b
Figure 2b
The MRI evaluates the left ventricular function during systole (upper panel) and diastole (lower panel) from the short axis view after stem cell therapy
Figure 3
Figure 3
(A) The delayed enhancement study showed multiple segments of the hyperenhancement represent the dead myocardium before stem cell therapy. (B) The delayed enhancement study showed multiple segments of the hyperenhancement represent the dead myocardium after stem cell therapy
See this image and copyright information in PMC

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