Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Jul 21;16(27):3402-5.
doi: 10.3748/wjg.v16.i27.3402.

Sessile serrated adenomas: demographic, endoscopic and pathological characteristics

Suryakanth R Gurudu  1 , Russell I Heigh, Giovanni De Petris, Evelyn G Heigh, Jonathan A Leighton, Shabana F Pasha, Isaac B Malagon, Ananya Das
Affiliations

Sessile serrated adenomas: demographic, endoscopic and pathological characteristics

Suryakanth R Gurudu et al. World J Gastroenterol. .

Abstract

Aim: To study the demographic and endoscopic characteristics of patients with sessile serrated adenoma (SSA) in a single center.

Methods: Patients with SSA were identified by review of the pathology database of Mayo Clinic Arizona from 2005 to 2007. A retrospective chart review was performed to extract data on demographics, polyp characteristics, presence of synchronous adenomatous polyps or cancer, polypectomy methods, and related complications.

Results: One hundred and seventy-one (2.9%) of all patients undergoing colonoscopy had a total of 226 SSAs. The mean (SE) size of the SSAs was 8.1 (0.4) mm; 42% of SSAs were < or = 5 mm, and 69% were < or = 9 mm. Fifty-one per cent of SSAs were located in the cecum or ascending colon. Approximately half of the patients had synchronous polyps of other histological types, including hyperplastic and adenomatous polyps. Synchronous adenocarcinoma was present in seven (4%) cases. Ninety-seven percent of polyps were removed by colonoscopy.

Conclusion: Among patients with colon polyps, 2.9% were found to have SSAs. Most of the SSAs were located in the right side and were safely managed by colonoscopy.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Sessile serrated adenoma. Flask-shaped glands with dilated and irregular architecture of the gland bases with abundant luminal mucin.
Figure 2
Figure 2
Distribution of sessile serrated adenomas in patient population.
Figure 3
Figure 3
Colonoscopic image of sessile serrated adenoma (sessile, flat with yellow appearance).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Vogelstein B, Fearon ER, Hamilton SR, Kern SE, Preisinger AC, Leppert M, Nakamura Y, White R, Smits AM, Bos JL. Genetic alterations during colorectal-tumor development. N Engl J Med. 1988;319:525–532. - PubMed
    1. Goldstein NS, Bhanot P, Odish E, Hunter S. Hyperplastic-like colon polyps that preceded microsatellite-unstable adenocarcinomas. Am J Clin Pathol. 2003;119:778–796. - PubMed
    1. Lindor NM, Burgart LJ, Leontovich O, Goldberg RM, Cunningham JM, Sargent DJ, Walsh-Vockley C, Petersen GM, Walsh MD, Leggett BA, et al. Immunohistochemistry versus microsatellite instability testing in phenotyping colorectal tumors. J Clin Oncol. 2002;20:1043–1048. - PubMed
    1. Higuchi T, Jass JR. My approach to serrated polyps of the colorectum. J Clin Pathol. 2004;57:682–686. - PMC - PubMed
    1. Iino H, Jass JR, Simms LA, Young J, Leggett B, Ajioka Y, Watanabe H. DNA microsatellite instability in hyperplastic polyps, serrated adenomas, and mixed polyps: a mild mutator pathway for colorectal cancer? J Clin Pathol. 1999;52:5–9. - PMC - PubMed