Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2010 Jul 15:6:14.
doi: 10.1186/1746-160X-6-14.

Human papillomavirus-mediated carcinogenesis and HPV-associated oral and oropharyngeal squamous cell carcinoma. Part 1: human papillomavirus-mediated carcinogenesis

Liviu Feller  1 , Neil H Wood, Razia A G Khammissa, Johan Lemmer
Affiliations
Review

Human papillomavirus-mediated carcinogenesis and HPV-associated oral and oropharyngeal squamous cell carcinoma. Part 1: human papillomavirus-mediated carcinogenesis

Liviu Feller et al. Head Face Med. .

Abstract

High-risk human papillomavirus (HPV) E6 and E7 oncoproteins are essential factors for HPV-induced carcinogenesis, and for the maintenance of the consequent neoplastic growth. Cellular transformation is achieved by complex interaction of these oncogenes with several cellular factors of cell cycle regulation including p53, Rb, cyclin-CDK complexes, p21 and p27. Both persistent infection with high-risk HPV genotypes and immune dysregulation are associated with increased risk of HPV-induced squamous cell carcinoma.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Flow chart of high-risk HPV pathogenesis of squamous cell carcinoma. By inactivation of p53, high-risk HPV E6 oncoprotein induces cell survival and delayed apoptosis, and HPV E7 oncoprotein through inactivation of Rb gene stimulates cellular DNA synthesis and pathological cell growth. The separate pathological activities of HPV E6 and E7 on the cell cycle complement each other and mediate the HPV-associated epithelial cell transformation.
See this image and copyright information in PMC

References

    1. Morin PJ, Trent JM, Collins FS, Vogelstein B. In: Harrisons principles of internal medicine. 16. Kasper DL, Braunwald E, Fauci AS, Hauser SL, Lango DL, Jameson JL, editor. New York: Graw-Hill; 2005. Cancer genetics; pp. 447–453.
    1. Fenton RG, Longo DL. In: Harrisons principles of internal medicine. 16. Kasper DL, Braunwald E, Fauci AS, Hauser SL, Lango DL, Jameson JL, editor. New York: Graw-Hill; 2005. Cancer cell biology and angiogenesis; pp. 453–464.
    1. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell. 2000;100:57–70. doi: 10.1016/S0092-8674(00)81683-9. - DOI - PubMed
    1. Vogelstein B, Kinzler KW. Cancer genes and the pathway they control. Nat Med. 2004;10:789–799. doi: 10.1038/nm1087. - DOI - PubMed
    1. Kinzler KW, Vogelstein B. Cancer-susceptibility genes. Gatekeepers and caretakers. Nature. 1997;386:761–763. doi: 10.1038/386761a0. - DOI - PubMed

MeSH terms