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Case Reports
. 2010 Jul;13(7):903-8.
doi: 10.1089/jpm.2010.9808.

Oral ketamine for the rapid treatment of depression and anxiety in patients receiving hospice care

Scott A Irwin  1 , Alana Iglewicz
Affiliations
Case Reports

Oral ketamine for the rapid treatment of depression and anxiety in patients receiving hospice care

Scott A Irwin et al. J Palliat Med. 2010 Jul.

Abstract

Depression is prevalent and undertreated in patients receiving hospice care. Standard antidepressants do not work rapidly or often enough to benefit most of these patients. Here, two cases are reported in which a single oral dose of ketamine provided rapid and moderately sustained symptom relief for both depression and anxiety. In addition, no adverse effects were noted. Further investigation with randomized, controlled clinical trials is necessary to firmly establish the effectiveness of oral ketamine for the treatment of depression and anxiety in patients receiving hospice care. Ketamine may be a promising safe, effective, and cost-effective rapid treatment for depression and anxiety in this population.

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Figures

FIG. 1.
FIG. 1.
Rating Scales for Case 1: (A) 17-item Hamilton Rating Scale for Depression and Hospital Anxiety and Depression Scale scores indicating a decrease in depressive and anxiety symptoms and (B) Adverse Symptom Checklist and Brief Psychiatric Rating Scale scores indicating an improvement in what would be considered unwanted symptoms or adverse effects.
FIG. 2.
FIG. 2.
Rating Scales for Case 2: (A) 17-item Hamilton Rating Scale for Depression and Hospital Anxiety and Depression Scale scores indicating a decrease in depressive and anxiety symptoms and (B) Adverse Symptom Checklist and Brief Psychiatric Rating Scale scores indicating an improvement in what would be considered unwanted symptoms or adverse effects.
See this image and copyright information in PMC

References

    1. Wilson KG. Chochinov HM. de Faye BJ. Breitbart W. Diagnosis, management of depression in palliative care. In: Chochinov HM, editor; Breitbart W, editor. Handbook of Psychiatry in Palliative Medicine. New York: Oxford University Press; 2000. pp. 25–50.
    1. National Institutes of Health. National Institutes of Health State-of-the-Science Conference Statement: Symptom Management in Cancer: Pain, Depression, and Fatigue, July 15–17, 2002. J Natl Cancer Inst Monographs. 2004;2004:9–16. - PubMed
    1. Wilson KG. Chochinov HM. Skirko MG. Allard P. Chary S. Gagnon PR. Macmillan K. De Luca M. O'Shea F. Kuhl D. Fainsinger RL. Clinch JJ. Depression and anxiety disorders in palliative cancer care. J Pain Symptom Manage. 2007;33:118–129. - PubMed
    1. Goldberg RJ. Mor V. A survey of psychotropic use in terminal cancer patients. Psychosomatics. 1985;26:745–748, 751. - PubMed
    1. McDaniel JS. Brown FW. Cole SA. Assessment of depression, grief reactions in the medically ill. In: Stoudemire A, editor; Fogel BS, editor; Greenberg DB, editor. Psychiatric Care of the Medical Patient. New York: Oxford University Press; 2000. pp. 149–164.

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