Randomized Controlled Trial
doi: 10.1016/j.fertnstert.2010.06.008.
Epub 2010 Jul 17.
Aromatase inhibitors in women with clomiphene citrate resistance: a randomized, double-blind, placebo-controlled trial
Affiliations
- PMID: 20638059
- DOI: 10.1016/j.fertnstert.2010.06.008
Item in Clipboard
Randomized Controlled Trial
Aromatase inhibitors in women with clomiphene citrate resistance: a randomized, double-blind, placebo-controlled trial
Fertil Steril.
2010 Dec.
Free article
Abstract
In 36 women with polycystic ovary syndrome and clomiphene citrate resistance, letrozole, an aromatase inhibitor, statistically significantly increased the ovulation rate by 33.3% in the treatment group, indicating that letrozole can be used as an effective and simple alternate ovulation-inducing agent in these women.
Copyright © 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Similar articles
-
Letrozole induction of ovulation in women with clomiphene citrate-resistant polycystic ovary syndrome may not depend on the period of infertility, the body mass index, or the luteinizing hormone/follicle-stimulating hormone ratio.Fertil Steril. 2006 Feb;85(2):511-3. doi: 10.1016/j.fertnstert.2005.08.016. Fertil Steril. 2006. PMID: 16595244
-
Use of the aromatase inhibitor letrozole for ovulation induction in women with polycystic ovarian syndrome.Clin Obstet Gynecol. 2011 Dec;54(4):685-95. doi: 10.1097/GRF.0b013e3182353d0f. Clin Obstet Gynecol. 2011. PMID: 22031258
-
Efficacy of letrozole in ovulation induction compared to that of clomiphene citrate in patients with polycystic ovarian syndrome.J Reprod Med. 2010 Jan-Feb;55(1-2):36-40. J Reprod Med. 2010. PMID: 20337206 Clinical Trial.
-
A new era in ovulation induction.Fertil Steril. 2006 Feb;85(2):277-84. doi: 10.1016/j.fertnstert.2005.05.078. Fertil Steril. 2006. PMID: 16595197 Review.
-
Aromatase inhibitors for ovulation and pregnancy in polycystic ovary syndrome.Ann Pharmacother. 2009 Jul;43(7):1338-46. doi: 10.1345/aph.1M096. Epub 2009 Jul 7. Ann Pharmacother. 2009. PMID: 19584394 Review.
Cited by
-
A Review of Second- and Third-line Infertility Treatments and Supporting Evidence in Women with Polycystic Ovary Syndrome.Med Sci (Basel). 2019 Jun 26;7(7):75. doi: 10.3390/medsci7070075. Med Sci (Basel). 2019. PMID: 31247909 Free PMC article. Review.
-
A Review of First Line Infertility Treatments and Supporting Evidence in Women with Polycystic Ovary Syndrome.Med Sci (Basel). 2019 Sep 10;7(9):95. doi: 10.3390/medsci7090095. Med Sci (Basel). 2019. PMID: 31510088 Free PMC article. Review.
-
Emulating a target trial of the comparative effectiveness of clomiphene citrate and letrozole for ovulation induction.Hum Reprod. 2022 Apr 1;37(4):793-805. doi: 10.1093/humrep/deac005. Hum Reprod. 2022. PMID: 35048945 Free PMC article.
-
Letrozole or clomiphene citrate as first line for anovulatory infertility: a debate.Reprod Biol Endocrinol. 2011 Jun 21;9:86. doi: 10.1186/1477-7827-9-86. Reprod Biol Endocrinol. 2011. PMID: 21693034 Free PMC article.
-
Pharmacological and Non-Pharmacological Interventions for Polycystic Ovary Syndrome (PCOS) in Indian Women: A Systematic Review and Meta-Analysis.Pharmaceuticals (Basel). 2025 May 2;18(5):680. doi: 10.3390/ph18050680. Pharmaceuticals (Basel). 2025. PMID: 40430499 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
