Untreated HIV: harmful even at high CD4 cell counts
- PMID: 20638117
- PMCID: PMC3523325
- DOI: 10.1016/S0140-6736(10)61033-1
Untreated HIV: harmful even at high CD4 cell counts
Conflict of interest statement
IVB declares that she has no conflicts of interest. PES is a consultant or scientific adviser for Abbott, Bristol-Myers Squibb, Gilead, Merck, Tibotec, and ViiV, and is receiving research grants for clinical trials from Gilead, Merck, and Tibotec.
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Comment in
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The science and practice of HIV prevention.Lancet. 2010 Jul 31;376(9738):304. doi: 10.1016/S0140-6736(10)61166-X. Lancet. 2010. PMID: 20674706 No abstract available.
Comment on
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Death rates in HIV-positive antiretroviral-naive patients with CD4 count greater than 350 cells per microL in Europe and North America: a pooled cohort observational study.Lancet. 2010 Jul 31;376(9738):340-5. doi: 10.1016/S0140-6736(10)60932-4. Epub 2010 Jul 15. Lancet. 2010. PMID: 20638118 Free PMC article.
References
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- Study Group on Death Rates at High CD4 Count in Antiretroviral Naive Patients. Death rates in HIV-positive antiretroviral-naive patients with CD4 count greater than 350 cells per μL in Europe and North America: a pooled cohort observational study. Lancet. 2010 doi: 10.1016/S0140-6736(10)60932-4. published online July 16. - DOI - PMC - PubMed
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- Bhaskaran K, Hamouda O, Sannes M, et al. for the CASCADE Collaboration. Changes in the risk of death after HIV seroconversion compared with mortality in the general population. JAMA. 2008;300:51–59. - PubMed
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- Lewden C, Chene G, Morlat P, et al. Agence Nationale de Recherches sur le Sida et les Hepatites Virales (ANRS) CO8 APROCO-COPILOTE and CO3 AQUITAINE Study Group. HIV-infected adults with a CD4 cell count greater than 500 cells/mm3 on long-term combination antiretroviral therapy reach same mortality rates as the general population. J Acquir Immune Defic Syndr. 2007;46:72–77. - PubMed
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- Lohse N, Hansen AB, Pedersen G, et al. Survival of persons with and without HIV infection in Denmark, 1995–2005. Ann Intern Med. 2007;146:87–95. - PubMed
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- van Sighem A, Gras L, Reiss P, Brinkman K, de Wolf F. Life expectancy of recently diagnosed asymptomatic HIV-infected patients approaches that of uninfected individuals. AIDS. 2010;24:1527–35. - PubMed
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