Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1991 May 1;39(2):196-200.
doi: 10.1002/ajmg.1320390215.

Characterization of deletions at the retinoblastoma locus in patients with bilateral retinoblastoma

K Kloss  1 , P Währisch, V Greger, E Messmer, H Fritze, W Höpping, E Passarge, B Horsthemke
Affiliations

Characterization of deletions at the retinoblastoma locus in patients with bilateral retinoblastoma

K Kloss et al. Am J Med Genet. .

Abstract

DNA samples from 92 unrelated patients with bilateral retinoblastoma were analyzed by Southern blot hybridization with cDNA and genomic clones of the retinoblastoma (RB-1) gene. Qualitative and quantitative evaluation of the Southern blot patterns showed a deletion of all or part of the RB-1 gene in 15 patients. Deletion hot spots were not detected. The study shows that 16% of germ cell mutations are detectable by Southern blot hybridization, but that densitometric analysis is required in most cases.

PubMed Disclaimer

Comment in

Publication types

LinkOut - more resources