Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Aug;42(8):658-60.
doi: 10.1038/ng.627. Epub 2010 Jul 18.

Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis

Xiangdong Liu  1 , Pietro Invernizzi, Yue Lu, Roman Kosoy, Yan Lu, Ilaria Bianchi, Mauro Podda, Chun Xu, Gang Xie, Fabio Macciardi, Carlo Selmi, Sara Lupoli, Russell Shigeta, Michael Ransom, Ana Lleo, Annette T Lee, Andrew L Mason, Robert P Myers, Kevork M Peltekian, Cameron N Ghent, Francesca Bernuzzi, Massimo Zuin, Floriano Rosina, Elisabetta Borghesio, Annarosa Floreani, Roberta Lazzari, Grazia Niro, Angelo Andriulli, Luigi Muratori, Paolo Muratori, Piero L Almasio, Pietro Andreone, Marzia Margotti, Maurizia Brunetto, Barbara Coco, Domenico Alvaro, Maria C Bragazzi, Fabio Marra, Alessandro Pisano, Cristina Rigamonti, Massimo Colombo, Marco Marzioni, Antonio Benedetti, Luca Fabris, Mario Strazzabosco, Piero Portincasa, Vincenzo O Palmieri, Claudio Tiribelli, Lory Croce, Savino Bruno, Sonia Rossi, Maria Vinci, Cleofe Prisco, Alberto Mattalia, Pierluigi Toniutto, Antonio Picciotto, Andrea Galli, Carlo Ferrari, Silvia Colombo, Giovanni Casella, Lorenzo Morini, Nicola Caporaso, Agostino Colli, Giancarlo Spinzi, Renzo Montanari, Peter K Gregersen, E Jenny Heathcote, Gideon M Hirschfield, Katherine A Siminovitch, Christopher I Amos, M Eric Gershwin, Michael F Seldin
Affiliations

Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis

Xiangdong Liu et al. Nat Genet. 2010 Aug.

Abstract

A genome-wide association screen for primary biliary cirrhosis risk alleles was performed in an Italian cohort. The results from the Italian cohort replicated IL12A and IL12RB associations, and a combined meta-analysis using a Canadian dataset identified newly associated loci at SPIB (P = 7.9 x 10(-11), odds ratio (OR) = 1.46), IRF5-TNPO3 (P = 2.8 x 10(-10), OR = 1.63) and 17q12-21 (P = 1.7 x 10(-10), OR = 1.38).

PubMed Disclaimer

Figures

Figure 1
Figure 1
Results of genome-wide association tests for PBC. (a,b) The ordinate shows the level of significance for each SNP along each chromosome (a) or the HLA region (b). The Italian PBC subset (diamond symbols) and combined European dataset (circle symbols) are shown. The dashed line corresponds to P = 5 × 10–8.
See this image and copyright information in PMC

Comment in

References

    1. Gershwin ME, Mackay IR. Hepatology. 2008;47:737–745. - PubMed
    1. Hirschfield GM, et al. N. Engl. J. Med. 2009;360:2544–2555. - PMC - PubMed
    1. Invernizzi P, et al. Hepatology. 2008;48:1906–1912. - PMC - PubMed
    1. Moffatt MF, et al. Nature. 2007;448:470–473. - PubMed
    1. McGovern DP, et al. Nat. Genet. 2010;42:332–337. - PMC - PubMed

Publication types

Substances