Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Dec 22;2010(4):591-594.
doi: 10.1055/s-0029-1219374.

Methodology for the Synthesis of Substituted 1,3-Oxazoles

David R Williams  1 , Liangfeng Fu
Affiliations

Methodology for the Synthesis of Substituted 1,3-Oxazoles

David R Williams et al. Synlett. .

Abstract

The halogen dance isomerization is a facile and preparatively effective pathway for the synthesis of 2,4,5-trisubstituted-1,3-oxazoles.

PubMed Disclaimer

Figures

Scheme 1
Scheme 1
Scheme 2
Scheme 2
See this image and copyright information in PMC

References

    1. Ichiba T, Yoshida WY, Scheuer PJ, Higa T, Gravalos DG. J. Am. Chem. Soc. 1991;113:3173–3174.
    1. Searle PA, Molinski TF. J. Am. Chem. Soc. 1995;117:8126–8131.

    1. For structure revision of diazonamide A: Li J, Burgett AWG, Esser L, Amezcua C, Harran PG. Angew. Chem. Int. Ed. 2001;40:4770–4773.

    1. Hagelueken G, Albrecht SC, Steinmetz H, Jansen R, Heinz DW, Kalesse M, Schubert W-D. Angew. Chem. Int. Ed. 2008;48:595–598. (b) For recent isolation of hemi-phorboxazole A: Dalisay DS, Molinski TF. Org. Lett. 2009;11:1967–1970.

    1. Shin-ya K, Wierzba K, Matsuo K, Ohtani T, Yamada Y, Furihata K, Hayakawa Y, Seto H. J. Am. Chem. Soc. 2001;123:1262–1263. - PubMed

LinkOut - more resources