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Review

2-[ methyl-11C]Methoxyestradiol

Kam Leung  1
In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004.
[updated ].
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Review

2-[ methyl-11C]Methoxyestradiol

Kam Leung.
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Excerpt

Endothelial cells are important cells in angiogenesis (1). Tumor growth requires the formation of new blood vessels. Potent angiogenic factors (e.g., vascular endothelial growth factor and basic fibroblast growth factor) induce proliferation, sprouting, migration, and tube formation of endothelial cells (2). 2-Methoxyestradiol (2-ME), an endogenous metabolite of 17β-estradiol, inhibits proliferating tumor cells and angiogenesis in vitro and in vivo (3, 4). It also inhibits the proliferation of endothelial cells and has low affinity for estrogen receptors. Huang et al. (5) demonstrated that the anti-proliferation effect of 2-ME may be the result of its inhibition of superoxide dismutase (SOD) and induction of apoptosis. Inhibition of SOD leads to free radical–mediated damage to mitochondrial membranes resulting in apoptosis. 2-[methyl-11C]Methoxyestradiol ([11C]2-ME) has been evaluated as an imaging probe to study angiogenesis (6).

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References

    1. Folkman J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med. 1995; 1 (1):27–31. - PubMed
    1. Distler J.H. , Hirth A. , Kurowska-Stolarska M. , Gay R.E. , Gay S. , Distler O. Angiogenic and angiostatic factors in the molecular control of angiogenesis. Q J Nucl Med. 2003; 47 (3):149–61. - PubMed
    1. Fotsis T. , Zhang Y. , Pepper M.S. , Adlercreutz H. , Montesano R. , Nawroth P.P. , Schweigerer L. The endogenous oestrogen metabolite 2-methoxyoestradiol inhibits angiogenesis and suppresses tumour growth. Nature. 1994; 368 (6468):237–9. - PubMed
    1. Klauber N. , Parangi S. , Flynn E. , Hamel E. , D'Amato R.J. Inhibition of angiogenesis and breast cancer in mice by the microtubule inhibitors 2-methoxyestradiol and taxol. Cancer Res. 1997; 57 (1):81–6. - PubMed
    1. Huang P. , Feng L. , Oldham E.A. , Keating M.J. , Plunkett W. Superoxide dismutase as a target for the selective killing of cancer cells. Nature. 2000; 407 (6802):390–5. - PubMed

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