123I-Interleukin-2

Review

¹²³I-Interleukin-2

In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004.

2005 Apr 29 [updated 2005 Aug 16].

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PMID: 20641904
Bookshelf ID: NBK23709

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Review

¹²³I-Interleukin-2

Kam Leung.

Free Books & Documents

In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004.

2005 Apr 29 [updated 2005 Aug 16].

Author

Kam Leung¹

Affiliation

¹ National Center for Biotechnology Information, NLM, NIH,

PMID: 20641904
Bookshelf ID: NBK23709

Excerpt

Interleukin-2 (IL-2) is a T-cell growth factor secreted by T lymphocytes (1). It stimulates the growth and differentiation of T cells, B cells, NK cells, LAK cells, monocytes, macrophages, and oligodendrocytes (2-4). High-affinity receptors are expressed mainly on activated T cells and macrophages (5), which infiltrate tumors, inflammatory tissues, and autoimmune tissues (6). Peripheral blood cells normally express very low levels of IL-2 receptor (7). ¹²³I-IL-2 has been developed as a single photon emission computed tomography (SPECT) tracer for imaging activated immune cells in tumors and pathological tissues (8, 9).

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References

1. Smith K.A. Interleukin 2. Annu Rev Immunol. 1984; 2 :319–33. - PubMed
1. Miyajima A. , Miyatake S. , Schreurs J. , De Vries J. , Arai N. , Yokota T. , Arai K. Coordinate regulation of immune and inflammatory responses by T cell-derived lymphokines. FASEB J. 1988; 2 (9):2462–73. - PubMed
1. Muraguchi A. , Kehrl J.H. , Longo D.L. , Volkman D.J. , Smith K.A. , Fauci A.S. Interleukin 2 receptors on human B cells. Implications for the role of interleukin 2 in human B cell function. J Exp Med. 1985; 161 (1):181–97. - PMC - PubMed
1. Smith K.A. Interleukin-2. Curr Opin Immunol. 1992; 4 (3):271–6. - PubMed
1. Smith K.A. The interleukin 2 receptor. Annu Rev Cell Biol. 1989; 5 :397–425. - PubMed

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- NCBI Bookshelf

[1] Smith K.A. Interleukin 2. Annu Rev Immunol. 1984; 2 :319–33. - PubMed

[2] Smith K.A. Interleukin 2. Annu Rev Immunol. 1984; 2 :319–33. - PubMed

[3] Miyajima A. , Miyatake S. , Schreurs J. , De Vries J. , Arai N. , Yokota T. , Arai K. Coordinate regulation of immune and inflammatory responses by T cell-derived lymphokines. FASEB J. 1988; 2 (9):2462–73. - PubMed

[4] Miyajima A. , Miyatake S. , Schreurs J. , De Vries J. , Arai N. , Yokota T. , Arai K. Coordinate regulation of immune and inflammatory responses by T cell-derived lymphokines. FASEB J. 1988; 2 (9):2462–73. - PubMed

[5] Muraguchi A. , Kehrl J.H. , Longo D.L. , Volkman D.J. , Smith K.A. , Fauci A.S. Interleukin 2 receptors on human B cells. Implications for the role of interleukin 2 in human B cell function. J Exp Med. 1985; 161 (1):181–97. - PMC - PubMed

[6] Muraguchi A. , Kehrl J.H. , Longo D.L. , Volkman D.J. , Smith K.A. , Fauci A.S. Interleukin 2 receptors on human B cells. Implications for the role of interleukin 2 in human B cell function. J Exp Med. 1985; 161 (1):181–97. - PMC - PubMed

[7] Smith K.A. Interleukin-2. Curr Opin Immunol. 1992; 4 (3):271–6. - PubMed

[8] Smith K.A. Interleukin-2. Curr Opin Immunol. 1992; 4 (3):271–6. - PubMed

[9] Smith K.A. The interleukin 2 receptor. Annu Rev Cell Biol. 1989; 5 :397–425. - PubMed

[10] Smith K.A. The interleukin 2 receptor. Annu Rev Cell Biol. 1989; 5 :397–425. - PubMed

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¹²³I-Interleukin-2

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