Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2010 Dec;16(6):348-61.
doi: 10.1111/j.1755-5949.2010.00184.x.

Targeting histone deacetylases for the treatment of Huntington's disease

Steven G Gray  1
Affiliations
Review

Targeting histone deacetylases for the treatment of Huntington's disease

Steven G Gray. CNS Neurosci Ther. 2010 Dec.

Abstract

Huntington's disease is a debilitating neurodegenerative condition with significant burdens on both patient and healthcare costs. Despite the identification of the causative element, an expanded toxic polyglutamine tract in the mutant Huntingtin protein, treatment options for patients with this disease remain limited. In the following review I assess the current evidence suggesting that a family of important regulatory proteins known as histone deacetylases may be an important therapeutic target in the treatment of this disease.

PubMed Disclaimer

Conflict of interest statement

The authors have no conflict of interest.

Figures

Figure 1
Figure 1
An overview of various pathways involving epigenetic regulators in Huntington's disease.
See this image and copyright information in PMC

References

    1. Walker FO. Huntington's disease. Lancet 2007;369:218–228. - PubMed
    1. DiFiglia M, Sapp E, Chase K, et al Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons. Neuron 1995;14:1075–1081. - PubMed
    1. Group THsDCR . A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell 1993;72:971–983. - PubMed
    1. Klement IA, Skinner PJ, Kaytor MD, et al. Ataxin‐1 nuclear localization and aggregation: Role in polyglutamine‐induced disease in SCA1 transgenic mice. Cell 1998;95:41–53. - PubMed
    1. Sieradzan KA, Mechan AO, Jones L, Wanker EE, Nukina N, Mann DM. Huntington's disease intranuclear inclusions contain truncated, ubiquitinated huntingtin protein. Exp Neurol 1999;156:92–99. - PubMed

MeSH terms