Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Jul;26(3):567-75, x-xi.
doi: 10.1016/j.ccc.2010.04.007.

Mitochondrial dysfunction and resuscitation in sepsis

Albert J Ruggieri  1 , Richard J Levy, Clifford S Deutschman
Affiliations

Mitochondrial dysfunction and resuscitation in sepsis

Albert J Ruggieri et al. Crit Care Clin. 2010 Jul.

Abstract

Sepsis is among the most common causes of death in patients in intensive care units in North America and Europe. In the United States, it accounts for upwards of 250,000 deaths each year. Investigations into the pathobiology of sepsis have most recently focused on common cellular and subcellular processes. One possibility would be a defect in the production of energy, which translates to an abnormality in the production of adenosine triphosphate and therefore in the function of mitochondria. This article presents a clear role for mitochondrial dysfunction in the pathogenesis and pathophysiology of sepsis. What is less clear is the teleology underlying this response. Prolonged mitochondrial dysfunction and impaired biogenesis clearly are detrimental. However, early inhibition of mitochondrial function may be adaptive.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Glycolytic Pathway (30).
Fig. 2
Fig. 2
Citric Acid Cycle (31).
Fig. 3
Fig. 3
The Electron Transport Chain (32).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Angus Derek C., Linde-Zwirble Walter T., Lidicker Jeffrey, et al. Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care. Critical Care Medicine. 2001;29:1303–1310. - PubMed
    1. Members of the American college of Chest Physicians /Society of Critical Care Consensus Committee American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: Definitions of sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Critical Care Medicine. 1992;20:864–874. - PubMed
    1. Levy Mitchell M., Fink Mitchell P., Marshall John C., et al. 2001 SCCM/ESICM/ACCP/ATS/SIS International sepsis definition conference. Critical Care Medicine. 2003;31:1250–1256. - PubMed
    1. Barcroft H, Allen WJ, Anderson DP, et al. Circulatory changes during fainting and coma caused by oxygen lack. Journal of Physiology. 1946;104:426–434. - PMC - PubMed
    1. Hotchkiss Richard S., Karl Irene E. Reevaluation of the role of cellular hypoxia and bioenergetic failure in sepsis. Journal of the American Medical Association. 1992;267:1503–1510. - PubMed