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Comment
. 2010 Jul 23;33(1):2-4.
doi: 10.1016/j.immuni.2010.07.008.

Follicular dendritic cell makes environmental sense

Jessy Deshane  1 , David D Chaplin
Affiliations
Comment

Follicular dendritic cell makes environmental sense

Jessy Deshane et al. Immunity. .

Abstract

Follicular dendritic cells (FDCs) are key organizers of B cell follicles and germinal centers. In this issue of Immunity, Suzuki et al. (2010) and Garin et al. (2010) identify the roles of Toll-like receptors in the responses of FDCs, providing a unique link between innate and adaptive immunity.

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Figures

Figure 1
Figure 1
FDCs integrate signals from TLR and other receptors to support an effective germinal center response. FDCs serve a critical organizing function in B cell follicles within secondary lymphoid tissues. Under stimulation by antigen, FDCs provide key signals for the development of the germinal center. In the Peyer's patch, shown here, signals delivered through cell surface Toll-like receptors (TLR) and through intracellular retinoic acid receptors (RAR) activate the FDC to support TGF-β-dependent B cell isotype switching to the production of IgA. In lymph nodes, TLR stimulation induces enhanced Ig somatic hypermutation and selection of high affinity variants.
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