A skeleton in the closet: neogenin guides bone development
- PMID: 20643341
- DOI: 10.1016/j.devcel.2010.07.004
A skeleton in the closet: neogenin guides bone development
Abstract
Bone Morphogenetic Proteins (BMPs) are key regulators of skeletal development. In this issue of Developmental Cell, Zhou et al. show that neogenin, a receptor for neuronal axon guidance, also regulates endochondral bone formation and BMP signaling and does so by influencing BMP receptor localization in membrane microdomains.
(c) 2010 Elsevier Inc. All rights reserved.
Comment on
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Neogenin regulation of BMP-induced canonical Smad signaling and endochondral bone formation.Dev Cell. 2010 Jul 20;19(1):90-102. doi: 10.1016/j.devcel.2010.06.016. Dev Cell. 2010. PMID: 20643353 Free PMC article.
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