Genome-wide association studies in Plasmodium species
- PMID: 20646263
- PMCID: PMC2903549
- DOI: 10.1186/1741-7007-8-90
Genome-wide association studies in Plasmodium species
Abstract
Genome-wide association studies (GWAS) look for correlations between traits of interest and genetic markers spread throughout the genome. A recent study in BMC Genetics has found that populations of the malaria parasite Plasmodium vivax should be amenable to GWAS searching for a genetic basis of parasite pathogenicity. Geographical substructure in populations may, however, prove a problem in interpreting the results.
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References
-
- Orjuela-Sanchéz P, Karunaweera ND, da Silva-Nunes M, da Silva N, Scopel KKG, Gonçlaves RM, Amaratunga C, Sá JM, Socheat D, Fairhurst RM, Gunawardena S, Thavakodirasah T, Galpaththy GNL, Abeysinghe R, Kawamoto F, Wirth DF, Ferreira MU. Single-nucleotide polymorphism, linkage disequilibrium and geographic structure in the malaria parasite Plasmodium vivax: prospects for genome-wide association studies. BMC Genet. 2010;11:65. doi: 10.1186/1471-2350-11-65. - DOI - PMC - PubMed
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