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Comment
. 2010 Jul 20;3(131):lc1; author reply lc2.
doi: 10.1126/scisignal.3131lc1.

Comment on "Increased MKK4 abundance with replicative senescence is linked to the joint reduction of multiple microRNAs"

Ugo Moens, Alexey Shiryaev, Gianina Dumitriu
Comment

Comment on "Increased MKK4 abundance with replicative senescence is linked to the joint reduction of multiple microRNAs"

Ugo Moens et al. Sci Signal. .

Abstract

Marasa et al. (Research Article, 27 October 2009, DOI: 10.1126/scisignal.2000442) reported that the human kinase p38-regulated/activated protein kinase (PRAK) was phosphorylated on residue Ser(93) in senescent cells. We have been unable to detect phosphorylation at this site with the antibody that they used, and the commercial supplier of this antibody has discontinued its availability, which casts doubt on whether this residue of PRAK is phosphorylated.

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