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Comment
. 2010 Jul 21;29(14):2258-9.
doi: 10.1038/emboj.2010.144.

Cell polarity/motility in bacteria: closer to eukaryotes than expected?

Emilia M F Mauriello  1
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Comment

Cell polarity/motility in bacteria: closer to eukaryotes than expected?

Emilia M F Mauriello. EMBO J. .
No abstract available

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Conflict of interest statement

The author declares that she has no conflict of interest.

Figures

Figure 1
Figure 1
The core of the Frz system, such as chemotaxis pathways in enteric bacteria, consists of a receptor, FrzCD, a histidine kinase, FrzE, a CheW-like coupling protein FrzA and a dual response regulator protein, FrzZ (Zusman et al, 2007). MglA and MglB are downstream of the Frz pathway. The Frz pathway might act as a direct or indirect GEF of MglA and mediate the accumulation of GTP-bound MglA at the leading pole. MglB, acting as a GAP, inhibits MglA localization at the lagging pole by keeping the concentration of GTP-bound MglA very low at this site. The MglA GTPase activity is essential to establish the correct polar localization of RomR and PilT, but not AlgZ. Mauriello et al (2010) showed that in the absence of MglA, AglZ and FrzS are mislocalized (AglZ also signals directly to FrzCD). In the absence of MglA, activity cells still reverse, suggesting the presence of a yet unproved regulatory activity of the Frz pathway on MglA (dashed line) and the existence of an intrinsic reversal clock.
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References

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