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Comment
. 2010 Jul 21;29(14):2260-1.
doi: 10.1038/emboj.2010.148.

Twins take the job

María-Eugenia Gas  1 , Bertrand Séraphin
Affiliations
Comment

Twins take the job

María-Eugenia Gas et al. EMBO J. .
No abstract available

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Figure 1
Figure 1
Schematic view of the composition and localization of human versus yeast exosomes. The nine subunit ring structure (exosome ring) is localized in the cytoplasm and nucleus in all eukaryotes. In human cells (left) the exosome ring interacts with the exoribonuclease RRP6 (hRRP6) and two different DIS3 paralogs: hDIS3 or hDIS3L1 (in a exclusive manner). Although hRRP6 is localized in the cytoplasm and nucleus, hDIS3 is mainly found in the nucleus (but excluded from nucleoli), and hDIS3L is strictly cytoplasmic. hDIS3 and hDIS3L1 are active exoribonucleases, but only the N-terminal PIN domain of hDIS3 is active (smile). In S. cerevisiae (yeast) cells (right), Dis3 protein (yDis3), which posses exoribonucleolytic and endonucleolytic activity, is present in the nucleus and cytoplasm and Rrp6 (yRrp6) is confined to the nucleus.
See this image and copyright information in PMC

Comment on

References

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