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. 2010 Sep 1;51(5):571-4.
doi: 10.1086/655697.

The decline of pneumococcal resistance after cessation of mass antibiotic distributions for trachoma

Sara Haug  1 , Takele Lakew, Gabremaskal Habtemariam, Wondu Alemayehu, Vicky Cevallos, Zhaoxia Zhou, Jenafir House, Kathryn Ray, Travis Porco, Tina Rutar, Jeremy Keenan, Thomas M Lietman, Bruce D Gaynor
Affiliations

The decline of pneumococcal resistance after cessation of mass antibiotic distributions for trachoma

Sara Haug et al. Clin Infect Dis. .

Abstract

After 6 biannual mass distributions of oral azithromycin for trachoma in Ethiopian communities, 76.8% (95% confidence interval [CI], 66.3%-85.1%) of nasopharyngeal Streptococcus pneumoniae isolates from children aged 1-5 years were resistant to macrolides. Twelve and 24 months after the last azithromycin treatment, resistance decreased to 30.6% (95% CI, 18.8%-40.4%; P <.001 ) and 20.8% (95% CI, 12.7%-30.7%; P < .001), respectively. Macrolide resistance decreases after antibiotic pressure is removed.

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