Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1991 Jun;48(6):382-8.
doi: 10.1136/oem.48.6.382.

Rapid changes in concentrations of essential elements in organs of rats exposed to methylmercury chloride and mercuric chloride as shown by simultaneous multielemental analysis

H Muto  1 , M Shinada, K Tokuta, Y Takizawa
Affiliations

Rapid changes in concentrations of essential elements in organs of rats exposed to methylmercury chloride and mercuric chloride as shown by simultaneous multielemental analysis

H Muto et al. Br J Ind Med. 1991 Jun.

Abstract

An in vivo study of rats given a dominant lethal dose of methylmercury chloride (MMC) or mercuric chloride (HgCl2) was conducted to elucidate the rapid biotransformation of essential elements. The elements were measured by inductively coupled plasma atomic emission spectrometry. For the rat brain Zn concentrations were higher in the MMC group than in the HgCl2 and control groups. The highest Cu concentration was found in HgCl2 dosed rat liver. For the rat kidney the highest Zn concentration was seen in the MMC group. From principal component analysis on the time dependent behaviour of each element in rat organs, characteristics specific to Cu in the liver and kidney and Mn in the brain were found after exposure to HgCl2 and Ca and Zn in the brain after exposure to MMC.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Br J Ind Med. 1968 Oct;25(4):315-8 - PubMed
    1. Biochim Biophys Acta. 1989 Nov 17;986(1):27-32 - PubMed
    1. Chem Biol Interact. 1980 Oct;32(1-2):125-35 - PubMed
    1. J Biol Chem. 1981 Apr 25;256(8):3931-5 - PubMed
    1. Biochem Pharmacol. 1982 Jan 15;31(2):137-42 - PubMed

MeSH terms

LinkOut - more resources