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Review
. 2010 Oct;31(5):756-73.
doi: 10.1210/er.2010-0003. Epub 2010 Jul 21.

Exposing the thyroid to radiation: a review of its current extent, risks, and implications

Bridget Sinnott  1 , Elaine Ron, Arthur B Schneider
Affiliations
Review

Exposing the thyroid to radiation: a review of its current extent, risks, and implications

Bridget Sinnott et al. Endocr Rev. 2010 Oct.

Abstract

Radiation exposure of the thyroid at a young age is a recognized risk factor for the development of differentiated thyroid cancer lasting for four decades and probably for a lifetime after exposure. Medical radiation exposure, however, occurs frequently, including among the pediatric population, which is especially sensitive to the effects of radiation. In the past, the treatment of benign medical conditions with external radiation represented the most significant thyroid radiation exposures. Today, diagnostic medical radiation represents the largest source of man-made radiation exposure. Radiation exposure related to the use of computerized tomography is rising exponentially, particularly in the pediatric population. There is direct epidemiological evidence of a small but significant increased risk of cancer at radiation doses equivalent to computerized tomography doses used today. Paralleling the increasing use of medical radiation is an increase in the incidence of papillary thyroid cancer. At present, it is unclear how much of this increase is related to increased detection of subclinical disease from the increased utilization of ultrasonography and fine-needle aspiration, how much is due to a true increase in thyroid cancer, and how much, if any, can be ascribed to medical radiation exposure. Fortunately, the amount of radiation exposure from medical sources can be reduced. In this article we review the sources of thyroid radiation exposure, radiation risks to the thyroid gland, strategies for reducing radiation exposure to the thyroid, and ways that endocrinologists can participate in this effort. Finally, we provide some suggestions for future research directions.

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Figures

Figure 1
Figure 1
Sources of radiation exposure in the United States, comparing 1980 and 2006.
Figure 2
Figure 2
Magnitude of radiation exposure from various sources. [Adapted from N. F. Metting: http://lowdose.energy.gov/imagegallery.aspx (32).] For cranial CT, the dose takes into account the multiple scans performed for the typical patient. GI, Gastrointestinal; PET, positron emission tomography.
See this image and copyright information in PMC

References

    1. Ron E, Lubin JH, Shore RE, Mabuchi K, Modan B, Pottern LM, Schneider AB, Tucker MA, Boice Jr JD 1995 Thyroid cancer after exposure to external radiation: a pooled analysis of seven studies. Radiat Res 141:259–277 - PubMed
    1. Sadetzki S 2007 Excess lifetime cancer mortality risk attributed to radiation exposure from pediatric computed tomography scan. Isr Med Assoc J 9:607–609 - PubMed
    1. Horner MJ, Ries LAG, Krapcho M, Neyman N, Aminou R, Howlader N, Altekruse SF, Feuer EJ, Huang L, Mariotto A, Miller BA, Lewis DR, Eisner MP, Stinchcomb DG, Edwards BK 2009 SEER cancer statistics review, 1975–2006. Bethesda, MD: National Cancer Institute (http://seer.cancer.gov/csr/1975_2006, based on November 2008 SEER data submission, posted to the SEER web site, 2009)
    1. Trimboli P, Ulisse S, Graziano FM, Marzullo A, Ruggieri M, Calvanese A, Piccirilli F, Cavaliere R, Fumarola A, D'Armiento M 2006 Trend in thyroid carcinoma size, age at diagnosis, and histology in a retrospective study of 500 cases diagnosed over 20 years. Thyroid 16:1151–1155 - PubMed
    1. Davies L, Welch HG 2006 Increasing incidence of thyroid cancer in the United States, 1973–2002. JAMA 295:2164–2167 - PubMed

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