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Comment
. 2010 Sep;177(3):1573-4; author reply 1574.
doi: 10.2353/ajpath.2010.100484. Epub 2010 Jul 22.

Cimetidine as an organic cation transporter antagonist

Comment

Cimetidine as an organic cation transporter antagonist

Hans Ehrsson et al. Am J Pathol. 2010 Sep.

Abstract

This Correspondence relates to “Organic transporter 2 mediates cisplatin-induced oto- and nephrotoxicity and is a target for protective interventions” (Am J Pathol 2010, 176:1169–1180).

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    1. Ciarimboli G, Deuster D, Knief A, Sperling M, Holtkamp M, Edemir B, Pavenstädt H, Lanvers-Kaminsky C, Zehnhoff-Dinnesen A, Schinke AH, Koepsell H, Jürgens H, Schlatter E. Organic cation transporter 2 mediates cisplatin-induced oto- and nephrotoxicity and is a target for protective interventions. Am J Pathol. 2010;176:1–12. - PMC - PubMed
    1. Corden BJ. Reaction of platinum(II) antitumor agents with sulfhydral compounds and the implications for nephrotoxicity. Inorg Chim Acta. 1987;137:125–130.
    1. El-Khateeb M, Appleton TG, Gahan LR, Charles BG, Berners-Price SJ, Bolton A-M. Reactions of cisplatin hydrolytes with methionine, cystein, and plasma ultrafiltrate studied by a combination of HPLC and NMR techniques. J Inorg Biochem. 1999;77:13–21. - PubMed
    1. Dabrowiak JC, Goodisman J, Souid A-K. Kinetic study of the reaction of cisplatin with thiols. Drug Metab Disp. 2002;30:1378–1384. - PubMed
    1. Verschraagen M, Kedde MA, Hausheer FH, van der Vijgh WJF. The chemical reactivity of BNP7787 and its metabolite mesna with the cytostatic agent cisplatin: comparison with the nucleophiles thiosulfate, DDTC, glutathione and its disulphide GSSG. Cancer Chemother Pharmacol. 2003;51:499–504. - PubMed

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