Genome instability: RB moonlights in mitosis

Comment

Gemma K Alderton. Nat Rev Mol Cell Biol. 2010 Aug.

. 2010 Aug;11(8):541.

doi: 10.1038/nrm2951.

No abstract available

Comment on

Loss of Rb proteins causes genomic instability in the absence of mitogenic signaling.
van Harn T, Foijer F, van Vugt M, Banerjee R, Yang F, Oostra A, Joenje H, te Riele H. van Harn T, et al. Genes Dev. 2010 Jul 1;24(13):1377-88. doi: 10.1101/gad.580710. Epub 2010 Jun 15. Genes Dev. 2010. PMID: 20551164 Free PMC article.
Loss of pRB causes centromere dysfunction and chromosomal instability.
Manning AL, Longworth MS, Dyson NJ. Manning AL, et al. Genes Dev. 2010 Jul 1;24(13):1364-76. doi: 10.1101/gad.1917310. Epub 2010 Jun 15. Genes Dev. 2010. PMID: 20551165 Free PMC article.
Mitotic chromosome condensation mediated by the retinoblastoma protein is tumor-suppressive.
Coschi CH, Martens AL, Ritchie K, Francis SM, Chakrabarti S, Berube NG, Dick FA. Coschi CH, et al. Genes Dev. 2010 Jul 1;24(13):1351-63. doi: 10.1101/gad.1917610. Epub 2010 Jun 15. Genes Dev. 2010. PMID: 20551166 Free PMC article.