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. 2009 Nov 11;1(1):87-92.
doi: 10.1159/000253874.

Primary Cutaneous Large B-Cell Lymphoma, Leg Type, Localized on the Dorsum

A Patrizi  1 , B Raone, E Sabattini, C Gurioli, A Pileri, C D'Acunto
Affiliations

Primary Cutaneous Large B-Cell Lymphoma, Leg Type, Localized on the Dorsum

A Patrizi et al. Case Rep Dermatol. .

Abstract

Primary cutaneous large B-cell lymphoma, leg-type (PCLBCL-LT), is a large B-cell lymphoma primarily involving the skin. It is distinguished from the other 3 subsets of this lymphoproliferative disorder by its immunohistopathological features, configuring confluent sheets of medium-sized to large B lymphocytes with round nuclei provided with evident nucleoli, resembling centroblasts or immunoblasts, which express Bcl-6, Bcl-2. Prevalently appearing on the lower limbs, as a single or multicentric and frequently ulcerated skin nodule or plaque, PCLBCL-LT has a worse prognosis than the other large B-cell lymphomas. Moreover, the age of onset is delayed (7th decade) compared to those of the other 3 subtypes (6th decade); it presents a slight female predominance (2:1), and a higher percentage of positivity to Bcl-2. We present a 52-year-old man who showed a 2-year standing, non-ulcerated, round, 4 cm in diameter, red plaque, medially located on the dorsum. After biopsy the diagnosis of PCLBCL-LT was made on histopathological and immunohistochemical studies, the latter showing positivity to CD20, Bcl-2, and Bcl-6. After treatment with radiotherapy the patient has shown a 4.4-year follow-up free of disease.

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Figures

Fig. 1
Fig. 1
Plaque on the dorsum, light red, firm and infiltrated.
Fig. 2
Fig. 2
Diffuse lymphocytic infiltrate in the papillary and reticular dermis. HE. Original magnification ×40.
Fig. 3
Fig. 3
Tumor cells contain cytoplasmic Bcl-2 staining. Bcl-2 immunoperoxidase. Original magnification ×64.
See this image and copyright information in PMC

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