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. 2011 Jan;21(1):113-21.
doi: 10.1007/s00330-010-1898-0. Epub 2010 Jul 23.

64-row MDCT perfusion of head and neck squamous cell carcinoma: technical feasibility and quantitative analysis of perfusion parameters

Lorenzo Faggioni  1 , Emanuele Neri, Francesca Cerri, Eugenia Picano, Veronica Seccia, Luca Muscatello, Stefano Sellari Franceschini, Carlo Bartolozzi
Affiliations

64-row MDCT perfusion of head and neck squamous cell carcinoma: technical feasibility and quantitative analysis of perfusion parameters

Lorenzo Faggioni et al. Eur Radiol. 2011 Jan.

Abstract

Objectives: To evaluate the technical feasibility of 64-row computed tomography (CT) quantitative perfusion imaging of head and neck squamous cell carcinoma (SCC).

Methods: Twenty-nine patients with a total of 29 pathologically proven SCC underwent a cine-mode CT perfusion acquisition covering the lesion site. The acquisition started 10 s after intravenous injection of iodinated contrast material and lasted 50 s. On a dedicated workstation, regions of interest (ROI) were traced within the SCC, on a healthy portion of tissue (H), and on the ipsilateral sternocleidomastoid muscle (M). Blood flow (BF), blood volume (BV), mean transit time (MTT) and permeability-surface product (PS) were calculated.

Results: In SCC, BF, BV and PS were higher compared with H (p<0.0001, p=0.002 and p=0.004, respectively) and M (p<0.0001). Conversely, MTT was lower in SCC than in H (p=0.0009) and M (p=0.0003). All datasets were free from substantial motion artefacts and ROI misregistration phenomena. No substantial discomfort or adverse events were experienced by any of the patients.

Conclusion: 64-row CT quantitative perfusion imaging allows head and neck SCC to be distinguished from normal tissues.

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