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Review
. 2010 Jul;30(1):1-12.
doi: 10.1007/s10059-010-0105-0. Epub 2010 Jul 14.

Reactive oxygen species in TNFalpha-induced signaling and cell death

Michael J Morgan  1 , Zheng-Gang Liu
Affiliations
Review

Reactive oxygen species in TNFalpha-induced signaling and cell death

Michael J Morgan et al. Mol Cells. 2010 Jul.

Abstract

TNFalpha is a pleotropic cytokine that initiates many downstream signaling pathways, including NF-kappaB activation, MAP kinase activation and the induction of both apoptosis and necrosis. TNFalpha has shown to lead to reactive oxygen species generation through activation of NADPH oxidase, through mitochondrial pathways, or other enzymes. As discussed, ROS play a role in potentiation or inhibition of many of these signaling pathways. We particularly discuss the role of sustained JNK activation potentiated by ROS, which generally is supportive of apoptosis and "necrotic cell death" through various mechanisms, while ROS could have inhibitory or stimulatory roles in NF-kappaB signaling.

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References

    1. Adler V, Yin Z, Fuchs SY, Benezra M, Rosario L, Tew KD, Pincus MR, Sardana M, Henderson CJ, Wolf CR, Davis RJ and Ronai Z (1999) Regulation of JNK signaling by GSTp. Embo J 18, 1321–1334. - PMC - PubMed
    1. Akimaru K, Utsumi T, Sato EF, Klostergaard J, Inoue M and Utsumi K (1992) Role of tyrosyl phosphorylation in neutrophil priming by tumor necrosis factor-alpha and granulocyte colony stimulating factor. Arch Biochem Biophys 298, 703–709. - PubMed
    1. Andrieu-Abadie N, Gouaze V, Salvayre R and Levade T (2001) Ceramide in apoptosis signaling: relationship with oxidative stress. Free Radic Biol Med 31, 717–728. - PubMed
    1. Anilkumar N, Weber R, Zhang M, Brewer A and Shah AM (2008) Nox4 and nox2 NADPH oxidases mediate distinct cellular redox signaling responses to agonist stimulation. Arterioscler Thromb Vasc Biol 28, 1347–1354. - PubMed
    1. Artal-Sanz M, Samara C, Syntichaki P and Tavernarakis N (2006) Lysosomal biogenesis and function is critical for necrotic cell death in Caenorhabditis elegans. J Cell Biol 173, 231–239. - PMC - PubMed

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