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. 1991 Jun;53(2):247-56.
doi: 10.1016/0165-4608(91)90101-y.

Uterine leiomyoma cytogenetics. II. Report of forty cases

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Uterine leiomyoma cytogenetics. II. Report of forty cases

R Vanni et al. Cancer Genet Cytogenet. 1991 Jun.

Abstract

Chromosome analysis of 40 cultured uterine leiomyomas revealed the presence of clonal changes in 32.5% of them, confirming the cytogenetic heterogeneity within this type of tumor, mostly referable to a few cytogenetic subgroups. Preferential involvement of 12q14-15 and 14q23-24 bands in reciprocal and complex translocations was most commonly observed. Deletions of chromosome 7 and changes of chromosomes 1, 2, and to a lesser extent, chromosomes 19 and 22 were also found. Constitutional karyotype of patients bearing tumors with karyotypic abnormalities was examined. In one patient, two cells were found with t(12;14)(q14-15;q23-24) translocation and two with del(14)(q13q23-24). The latter rearrangement was also present as a clonal change in the tumor.

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