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. 2010 Aug;96(2):161-5.
doi: 10.1016/j.radonc.2010.04.015.

MRI-based low dose-rate brachytherapy experience in locally advanced cervical cancer patients initially treated by concomitant chemoradiotherapy

Christine Haie-Meder  1 , Cyrus Chargari, Annie Rey, Isabelle Dumas, Philippe Morice, Nicolas Magné
Affiliations

MRI-based low dose-rate brachytherapy experience in locally advanced cervical cancer patients initially treated by concomitant chemoradiotherapy

Christine Haie-Meder et al. Radiother Oncol. 2010 Aug.

Abstract

Purpose: To retrospectively assess the physics contributions and the clinical outcome with preliminary 3D MRI-guided low dose-rate (LDR) intracavitary brachytherapy (BT) experience in locally advanced cervical cancer patients.

Patients and methods: Eighty-four patients with primary locally advanced cervical carcinoma were analyzed. The median tumoral cervical volume was 48.0 cc (range 1-468 cc). Twenty-four patients (53%) had histological and/or radiological pelvic involvement. After pelvic+/-paraaortic concomitant chemoradiation, a LDR BT boost was delivered to a 3D MRI-based clinical target volume taking into account dose volume constraints for critical organs and optimization of target volume coverage.

Results: With a median follow-up of 53 months (range 31-79 months), the 4-year overall survival and disease-free survival rates were 57 (95%CI, 43-69) and 52% (95%CI, 40-64), respectively. Adding EBRT and LDR using EQD2 model, the median D(100) and D(90) for the IR-CTV were 56.5 Gy(alpha/beta10) (range 37-83 Gy(alpha/beta10)) and 69 Gy(alpha/beta10) (range 52-113 Gy(alpha/beta10)), respectively. For HR-CTV, the median D(100) and D(90) were 67 Gy(alpha/beta10) (range 47-119 Gy(alpha/beta10)) and 79 Gy(alpha/beta10) (range 53-122 Gy(alpha/beta10)), respectively. Thirty-nine late complications were observed in 28 patients (33.3%): 13 bladder, 7 rectal, 5 small bowel, 4 urethral, 3 colic, 2 vaginal, 1 pelvic fibrosis, and 4 others. Four grade 3 delayed complications were observed and no grade 4 complication occurred.

Conclusions: Applying an individual treatment planning with 3D MRI-guided LDR brachytherapy appears to be feasible and efficient for patients with locally advanced cervical cancer in routine clinical practice.

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