Logarithmic dose transformation in epidemiologic dose-response analysis: use with caution

Abstract

Dose-response models based on the logarithm of dose or exposure are utilized in the analysis of both toxicological and epidemiologic data. While the applications are similar, fundamental differences in the studies conducted by each discipline affects the interpretation of the use of the logarithmic dose transformation. Using numerical illustrations and examples from the literature, this paper explores the implications of using logarithmic dose transformation in epidemiologic studies and provides some caveats for consideration in interpreting epidemiologic studies based upon logarithmic dose transformation.