MicroRNAs: genetically sensitized worms reveal new secrets
- PMID: 20656201
- DOI: 10.1016/j.cub.2010.05.054
MicroRNAs: genetically sensitized worms reveal new secrets
Abstract
Why do many microRNA gene mutants display no evident phenotype? Multiply mutant worms that are selectively impaired in genetic regulatory network activities have been used to uncover previously unknown functions for numerous Caenorhabditis elegans microRNAs.
2010 Elsevier Ltd. All rights reserved.
Comment on
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Many families of C. elegans microRNAs are not essential for development or viability.Curr Biol. 2010 Feb 23;20(4):367-73. doi: 10.1016/j.cub.2009.12.051. Epub 2010 Jan 21. Curr Biol. 2010. PMID: 20096582 Free PMC article.
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Loss of individual microRNAs causes mutant phenotypes in sensitized genetic backgrounds in C. elegans.Curr Biol. 2010 Jul 27;20(14):1321-5. doi: 10.1016/j.cub.2010.05.062. Epub 2010 Jun 24. Curr Biol. 2010. PMID: 20579881 Free PMC article.
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