Comment
doi: 10.1073/pnas.1008518107.
Epub 2010 Jul 23.
Increasing the specificity of neurotrophic factors
Affiliations
- PMID: 20656936
- PMCID: PMC2922268
- DOI: 10.1073/pnas.1008518107
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Comment
Increasing the specificity of neurotrophic factors
Proc Natl Acad Sci U S A.
.
No abstract available
Conflict of interest statement
The author declares no conflict of interest.
Figures
A link between GDNF and protocadherins. A multitude of different protocadherin proteins are expressed in the nervous system. Each transmembrane protocadherin possesses six extracellular cadherin domains and a short cytoplasmic segment. In the mouse, there are 14 protocadherin-α genes, 22 protocadherin-β genes, and 22 protocadherin-γ genes, which undergo multiple splicing events (16, 17). The GDNF family of ligands (GDNF, neurturin, artemin, and persephin) bind to individual GDNF-α receptors (GFR-α), which form a complex with the RET tyrosine kinase (5). The specific protocadherin proteins α4 and γb7 are phosphorylated by RET after GDNF treatment, which, in turn, stabilizes RET and delays its degradation (2).
Comment on
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Phosphorylation of protocadherin proteins by the receptor tyrosine kinase Ret.Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13894-9. doi: 10.1073/pnas.1007182107. Epub 2010 Jun 25. Proc Natl Acad Sci U S A. 2010. PMID: 20616001 Free PMC article.
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