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Comment
. 2010 Aug 3;107(31):13565-6.
doi: 10.1073/pnas.1008518107. Epub 2010 Jul 23.

Increasing the specificity of neurotrophic factors

Moses V Chao  1
Affiliations
Comment

Increasing the specificity of neurotrophic factors

Moses V Chao. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1.
Fig. 1.
A link between GDNF and protocadherins. A multitude of different protocadherin proteins are expressed in the nervous system. Each transmembrane protocadherin possesses six extracellular cadherin domains and a short cytoplasmic segment. In the mouse, there are 14 protocadherin-α genes, 22 protocadherin-β genes, and 22 protocadherin-γ genes, which undergo multiple splicing events (16, 17). The GDNF family of ligands (GDNF, neurturin, artemin, and persephin) bind to individual GDNF-α receptors (GFR-α), which form a complex with the RET tyrosine kinase (5). The specific protocadherin proteins α4 and γb7 are phosphorylated by RET after GDNF treatment, which, in turn, stabilizes RET and delays its degradation (2).
See this image and copyright information in PMC

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References

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    1. Schalm SS, Ballif BA, Buchanan SM, Phillips GR, Maniatis T. Phosphorylation of protocadherin proteins by the receptor tyrosine kinase Ret. Proc Natl Acad Sci USA. 2010;107:13894–13899. - PMC - PubMed
    1. Lin LF, Doherty DH, Lile JD, Bektesh S, Collins F. GDNF: A glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science. 1993;260:1130–1132. - PubMed
    1. Pérez-García MJ, et al. Glial cell line-derived neurotrophic factor increases intracellular calcium concentration. Role of calcium/calmodulin in the activation of the phosphatidylinositol 3-kinase pathway. J Biol Chem. 2004;279:6132–6142. - PubMed
    1. Paratcha G, Ledda F. GDNF and GFRalpha: A versatile molecular complex for developing neurons. Trends Neurosci. 2008;31:384–391. - PubMed

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