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. 2010 May 28;15(6):3887-904.
doi: 10.3390/molecules15063887.

Synthesis and adrenolytic activity of new propanolamines

Grazyna Groszek  1 , Agata Bajek, Agnieszka Bis, Agnieszka Nowak-Król, Marek Bednarski, Agata Siwek, Barbara Filipek
Affiliations

Synthesis and adrenolytic activity of new propanolamines

Grazyna Groszek et al. Molecules. .

Abstract

The synthesis of (2R,S)-1-(6-methoxy-4-(methoxymethyl)-1H-indol-5-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)propan-2-ol and (2R,S)-1-(4-methoxy-6-(methoxymethyl)-1H-indol-5-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)propan-2-ol is described. The compounds were tested for electrographic, antiarrhythmic, hypotensive, and spasmolytic activity, as well as for alpha(1)-, alpha(2)- and beta(1)-adrenoceptor binding affinity.

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Figures

Figure 1
Figure 1
Chemical structure of the compound (R,S)-9.
Figure 2
Figure 2
Synthetic pathway.
Figure 3
Figure 3
Changes in mean blood pressure after iv administration of the tested compounds in the lowest effective doses.
Figure 4
Figure 4
Changes in mean blood pressure after po administration of the tested compounds in the lowest effective doses.
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