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. 2010 Jun 4;15(6):4033-40.
doi: 10.3390/molecules15064033.

Synthesis and in vitro cytotoxicity of novel ursolic acid derivatives

Yanqiu Meng  1 , Yanling Song, Zhaokai Yan, Yan Xia
Affiliations

Synthesis and in vitro cytotoxicity of novel ursolic acid derivatives

Yanqiu Meng et al. Molecules. .

Abstract

In an effort to improve potential hepatoprotective and anti-tumor activities, eight novel ursolic acid (UA) derivatives were designed and synthesized with substitution at positions of C-3, C-11 and C-28 of UA. Their structures were confirmed using IR, MS and (1)H-NMR and elemental analysis. Their in vitro cytotoxicity against various cancer cell lines (HeLa, SKOV3 and BGC-823) was evaluated by the standard MTT assay. Among them, compound 13 exhibited more potent cytotoxicity than ursolic acid.

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Figures

Scheme 1
Scheme 1
Synthesis of Ursolic acid derivatives.
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