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. 1991 Jun 15;47(6):619-22.
doi: 10.1007/BF01949889.

Long-term depressor effects of catecholamine neuronal grafts in the third ventricle of the brain in normotensive rats

R Hashimoto  1 , F Kimura
Affiliations

Long-term depressor effects of catecholamine neuronal grafts in the third ventricle of the brain in normotensive rats

R Hashimoto et al. Experientia. .

Abstract

Neuronal tissue containing A-6 group noradrenalin (NA) neurons of the locus ceruleus, or A-10 group dopamine (DA) neurons of the substantia nigra, was grafted into the third ventricle at the level of the preoptic-anterior hypothalamic region, in normotensive male rats. A significant and long-lasting depressor effect was shown in rats with either graft. In rats with an NA neuron-rich graft, plasma concentrations of arginine-vasopressin (AVP), plasma renin activity (PRA), and corticosterone (CS) decreased significantly, whereas in rats with a DA neuron-rich graft, AVP and PRA concentrations also decreased significantly but CS showed no significant change. Neither NA nor adrenalin in plasma changed significantly in rats with either graft.

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